GENESIS: Publication

Related Documentation:
Model Citation, HH Equations, Figure 1, Morphology, Kinetic Parameters, NaF Current, NaP Current, CaT Current, CaP Current, Kh Current, Kdr Current, Km Current, Ka Current, Kc Current, K2 Current, Leak Current.

De Schutter: Purkinje Cell Model

Abstract Item 1

A detailed compartmental model of a cerebellar Purkinje cell with active dendritic membrane was constructed. The model was based on anatomic reconstructions of single Purkinje cells and included 10 different types of voltage-dependent channels described by Hodgkin-Huxley equations, derived from Purkinje cell specific voltage-clamp data where available. These channels included a fast and persistent Na⁺ channel, three voltage-dependent K⁺ channels, T-type and P-type Ca²⁺ channels, and two types of Ca²⁺ -activated K+ channels.