GENESIS: Documentation

Related Documentation:

De Schutter: Purkinje Cell Model

Table 1

Table 1: Er, and the parameters to Eq. 1-5 for the conductance of voltage- and Ca2+-dependent channels n the model, and abbreviations for the different ionic channels.
Name AbbreviationEr FactorPA B C D E FG H
Fast sodium NaF 45 m 3 35.0 0 5 -10.07.0 0 65 20.0
h 1 0.255 1 80 10.0 7.5 0 -3 -18.0
Persistent sodium NaP 45 m 3 200.0 1 -18-16.025.0 1 58 8.0
P calcium CaP 135m 1 8.5 1 -8 -12.535.0 1 74 14.5
h 1 0.0015 1 29 8.0 0.00551 23 -8.0
T calcium CaT 135m 1 2.60 1 21 -8.0 0.180 1 40 4.0
h 1 0.0025 1 40 8.0 0.190 1 50 -10.0
Anomalous rectifier Kh [1] -30
Delayed rectifier Kdr [2] -85
Persistant potassium KM ‡[2] -85
A KA -85 m 4 1.40 1 27 -12.00.490 1 30 4.0
h 1 0.0175 1 50 8.0 1.30 1 13 -10.0
BK calcium-activatedKC -85 m 1 7.5, αm is constant 10 0.110 0 -3514.9
z 2 4.00 2
K2 calcium activated K2 -85 m 1 25.0, αm is constant10 0.075 0 5 10.0
z 2 0.20 2
‡ Adjusted value: All rate constants ×5. E r: reversal potential, m: voltage-dependent activation gate, h: voltage-dependent inactivation gate, z: Ca2+-dependent activation gate, α m: voltage-independent activation.

References

[1]   Schwindt P C Spain W J and Crill W E. Anomolous rectification in neurons from cat sensorimotor cortex in vitro. Journal of Nerurophysiology, 57:1555–1576, 1987.

[2]   Koch C Yamada W and Adams P R. Multiple channels and calcium dynamics. In Koch C and Segev I, editors, From Synapses to Networks, pages 97–133. MA: MIT Press, 1989.