GENESIS: Documentation

De Schutter: Purkinje Cell Model

Figure 1:

Activation properties of the persistent K⁺ current (Km, - - -, no inactivation) in the model. Seady-state activation vs. voltage is plotted at the left and the time constant of activation (τ_m) vs. voltage on the right (Note: Semilogarithmic scale). The Km current does not inactivate.

Persistent Potassium Current (Km)

Noninactivating K⁺ channels in Purkinje cells have been reported by [1] and are also apparent in recordings from [2]. No kinetic data were available from Purkinje cells, so we have again used the equations of [3] for the noninactivating muscarinic K⁺ channel (Km).

References

[1] JL Bossu, JL Dupont, and A Feltz. Calcium currents in rat cerebellar Purkinje cells maintained in culture. Neuroscience, 30:605–617, 1989.

[2] T Hirano and S Hagiwara. Kinetics and distribution of voltage-gated Ca, Na, and K channels on the somata of rat cerebellar Purkinje cells. Pfluegers Archiv, 413:463–469, 1989.

[3] Koch C Yamada W and Adams P R. Multiple channels and calcium dynamics. In Koch C and Segev I, editors, From Synapses to Networks, pages 97–133. MA: MIT Press, 1989.