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Passive Membrane Properties, Channel Kinetics, Morphology Discretization
Simulations were performed with the neuronal simulation program GENESIS [3] on eight Sun Sparc2 workstations. We used the Hines algorithm [2] available in GENESIS versions 1.3 and 1.4. The GENESIS implementation of this algorithm is fast and accurate [1]. The simulations were run with a time step of 20 μs. Initial control simulations at 10 μs showed that the 20 μs step produced numerically accurate results. For the model presented here, 550 ms of Purkinje cell activity could be simulated in 1 h. Several thousand simulations were run, mostly to explore parameter space.
[1] US Bhalla, DH Bilitch, and JM Bower. Rallpacks: A set of benchmarks for neuronal simulators. TRENDS in Neurosciences, 15(11):453–458, 1992.
[2] M Hines. Efficient computation of branched nerve equations. International Journal of Bio-Medical Computing, 15:69–76, 1984.
[3] MA Wilson and JM Bower. The simulation of large-scale neuronal networks. In C Koch and I Segev, editors, Methods in Neuronal Modeling, pages 291–334. MIT Press, 1989.