| Figure 1: | Simulation of voltage-clamp steps. A: Model was clamped
at resting potential (-68 mV) and then stepped to -100 or +40 mV.
Superimposed top traces: membrane potential in the soma (s), main dendrite
(m), and a distal spiny dendrite (d, marked with asterisk in Fig. 1). Bottom
trace: clamp current. B: as in A, but stepped to -40 mV. C: membrane
potential under steady-state voltage clamp vs. distance from the soma. Data
from the same voltage-clamp steps as shown in A and B. Data points
are exclusively from compartments linking the soma with the distal spiny
dendrite. Because the potential oscillated during steps to -40 mV, 2 traces are
shown for that voltage step (corresponding to the minimum and maximum
voltage in the spiny dendrite). Simulation time step was 5 μs. |
