# Channel modeling, Traub model, and Neurokit

This set of exercises was used at the Latin American School on Computational Neuroscience (LASCON) to get students to the point of quickly creating cell models.

## Suggested reading in BoG

- Chapt. 7 - Ion Channels and Bursting Neurons
  - V and Ca activated channels
  - Case study of genesis/Scripts/burster model
  - Neurokit experiments with genesis/Scripts/traub91
- Chapt. 19 (1st ed: 18) - Implementing Other Types of Channels (Use of tabchannels)
- Chapt. 16 (1st ed: 15) - Cell Construction with the Cell Reader
- Chapt. 17 (1st ed: 16) - Building a Cell With Neurokit
- Chapt. 20 (1st ed: 19) - Last part: using hsolve

## Project suggestion

Pick an intresting neuron for which (ideally):

- There is no GENESIS model
- Important channels have been identified
- Some voltage clamp data is available
- Some current clamp data is available

THEN

- Make simplifed morphology ("ball and stick" or "reduced morpholgy")
- Implement channels
  - starting from scratch, or
  - modifying existing GENESIS channels (Scripts/neurokit/prototypes
- Perform parameter seach
  - manually (possibly with Neurokit)
  - automatically (see Reference Manual "Parameter Search Library")

## Back to the index of exercises