Clchan - Ca-dependent chloride channel

Fabio Marques Simoes de Souza has contributed a GENESIS model of the unusual calcium-dependent chloride channel (Kurahashi and Yau, 1994) of the olfactory sensory neurons. This model channel was used in the simulation of a vertebrate receptor cell of the olfactory epithelium (Simoes-de-Souza and Roque, 2002).

It is based in the experimental results of Hallani et al. (1998), Reuter et al. (1998) and Larson et al. (1997).

The directory Clchan and the gzipped tar file Clchan.tar.gz contain the simulation script CLCHAN.g and files that describe the model, the equations used, and the origin of the parameter values. These files are provided in PDF, postscript, and Rich text Format formats.

References:

Kurahashi, T. and Yau, K. (1994) Tale of an unusual chloride current. Current Biology, 4: 256-258.

Simoes-de-Souza, F.M. and Roque, A.C. (2002) Simulation of a vertebrate receptor cell of the olfactory epithelium for use in network models. Neurocomputing, 44-46: 177-182.

Hallani, M.; Lynch, J.W.; Barry, P.H. (1998) characterization of calcium-activated chloride channels in patches excised from the dendritic knob of mammalian olfactory receptor neurons. J. Membrane Biology, 161: 163-171.

Reuter,D.; Zierold, K.; Schröder, W.H.; Frings, S. (1998) A depolarizing chloride current contributes to chemoelectrical tranduction in olfactory sensory neurons in situ. J. Neuroscience, 18: 6623-6630.

Larson, H.P.; Kleene, S.J.; Lecar, H. (1997) Noise analyses of ion channels in non-space-clamped cables: estimates of channel parameters in olfactory cilia. Biophysical J., 72: 1193-1203.