Main simulation script: RScell.g
Model description:
This is a very simple one-compartment model of a neocortical regular spiking pyramidal cell that, in addition to a fast sodium current and delayed rectifier potassium current, uses a Muscarinic potassium current (KM) in order to achieve spike frequency adaption. This model is based on the paper and simulation by
Destexhe, A., Rudolph, M., Fellous, J. M. and Sejnowski, T. J. Fluctuating synaptic conductances recreate in-vivo-like activity in neocortical neurons. Neuroscience 107: 13-24 (2001).
The simplicity of the cell model makes it suitable for use in large network models that need to run quickly.
The simulation is based on a sample script to create a neuron from a specified cell parameter file, with channels taken from the prototypes created by the file protodefs.g. It can be customized for another cell by changing strings that are defined in the main script. When used with the GUI functions defined in graphics.g, it allows a variety of pulsed current injection and synaptic inputs to be applied.
The CONTROL PANEL of the GUI (defined in graphics.g) allows injection current pulses to be applied to the cell, and/or synaptic activation to be applied to the synchan that is specified in the string variable 'synpath'. If the value of synpath is '' (empty), then the synaptic input form does not appear. The injection may be turned on and off by clicking on the 'Current Injection ON/OFF' toggle.
In the synaptic input form, 'gmax' is used to set the gmax field of the specied synchan. Poisson-distributed background activation can be applied to the synchan by setting the 'Frequency' (the average activation frequency) to a non-zero value. This sets the frequency field of the synchan to that value. The 'Spike input ON/OFF' toggle turns on and off the application of trains of spikes at the specified 'Spike interval'.
The files in this directory are:
README This file.
RScell.g The main simulation script to start the simulation.
RScell.p The cell parameter file for the model
protodefs.f File to create the library of prototype channels and other
elements used by the cell parameter file.
graphics.g A generic GUI to control the simulation. It can be somewhat
customized by setting the value of parameters and strings
the main simulation script.
userprefs.g Used to run the model under Neurokit. Simply type
'genesis Neurokit' when in this directory, and then click
on 'file' when the title bar appears. Then click on
'Load from file', and then select 'run cell' from the
title bar. For help with Neurokit, run it from the
genesis/Scripts/neurokit directory.
These scripts are used and analyzed in the GENESIS Neural Modeling Tutorials package, which available from the GENESIS web site (http://genesis-sim.org/GENESIS).