The simulation is launched by typing genesis main.g After that, the simulation can be started for a certain time t by typing step t -time at the GENESIS prompt, where t is in seconds. Alternatively, the simulation can be started for a certain number of time steps n by typing step n In order to produce data stored in ascii-files, you have to create a directory DATA before starting the simulation with the step command. Since the simulation does not provide any direct graphical output, you should store data to ascii-files and visualize it by means of e.g. Matlab or xplot. If your computer has problems to handle many outputfiles, you can reduce their number in the file ascii_output41.g, by e.g. reducing the counters. Somatic membrane potentials of selected cells and extracellular potentials recorded by simulated electrodes are stored by means of this file. The file spikehist2409.g creates another set of ascii-files, where only the points in time of spike-initiation of selected cells get stored. About the other files: ====================== The core of the simulation is the file main.g. This file imports everything else. The comments should guide your way. The second most important file is maybe constants41.g. Almost every constant needed is defined in this file. The cell descriptor files are implicitely imported by the readcell-commands in cell_arrays41.g. Currently, I use hsolve with chanmode 1. Integration method is Crank- Nicolson. I run the simulation on a SGI with XEON-processor under Linux Suse 7.3 and GENESIS 2.2, but none of the new features of GENESIS 2.2 is applied. A simulation of 100 msec takes approximately 5 minutes on the above mentioned machine. For more information about the set-up of the simulation, please have a look at my diploma thesis, Chapter 2. Enjoy!